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Vaccine. 2010 Oct 18;28(44):7143-5. doi: 10.1016/j.vaccine.2010.08.084. Epub 2010 Sep 9.

Efficacy of a single dose hepatitis B depot vaccine.

Author information

1
ImmunoVaccine Technologies Inc., 1721 Lower Water St. Halifax, Nova Scotia, Canada.

Abstract

A single dose formulation of a novel hepatitis B vaccine, consisting of an adjuvant emulsion of liposomes in oil was produced at a manufacturing scale and delivered to rabbits. This single dose vaccine generated a significantly higher antibody response than two doses of an alum-adjuvanted control vaccine in the short term, and was as effective as three doses of the control vaccine in the long term.

PMID:
20832491
DOI:
10.1016/j.vaccine.2010.08.084
[Indexed for MEDLINE]

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