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Trends Microbiol. 2010 Nov;18(11):487-93. doi: 10.1016/j.tim.2010.08.002. Epub 2010 Sep 9.

Mucosal immunity in resource-limited setting: is the battle ground different?

Author information

1
Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi. sarah.glennie@liverpool.ac.uk

Abstract

In many developing countries, populations are under considerable pressure from high bacterial exposure on mucosal surfaces. Immune dysregulation in this setting is multifactorial and is driven by a range of environmental factors, undernutrition and coinfections such as measles, malaria and HIV. Disruption or subversion of respiratory-tract and intestinal epithelial barriers leads to increased invasion by mucosal pathogens and a high frequency of life-threatening bacterial disease. It is our opinion that a process of epithelial barrier dysfunction and immune dysregulation at these mucosal surfaces leads to the much higher rates of pneumonia, meningitis and severe sepsis seen in resource-limited countries.

PMID:
20832319
DOI:
10.1016/j.tim.2010.08.002
[Indexed for MEDLINE]

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