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Brain Dev. 2011 Jun;33(6):518-20. doi: 10.1016/j.braindev.2010.07.013. Epub 2010 Sep 15.

L-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation.

Author information

1
Department of Pediatrics, Matsuyama Shimin Hospital, Ohtemachi 2-6-5, Matsuyama, Ehime 791-0067, Japan.

Abstract

We report a case involving a 15-year-old boy with MELAS (G13513A mutation) who developed several stroke-like episodes in a short period of time. Intravenous administration of l-arginine during the acute phase of the stroke-like episodes reduced symptoms immediately, and oral supplementation of l-arginine successfully prevented further stroke-like episodes. This is the first report on effective l-arginine therapy in MELAS associated with the G13513A mutation.

PMID:
20832210
DOI:
10.1016/j.braindev.2010.07.013
[Indexed for MEDLINE]

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