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J Clin Pharm Ther. 2010 Aug;35(4):483-5. doi: 10.1111/j.1365-2710.2009.01108.x.

The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review.

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Faculty of Pharmacy, Silpakorn University, Thailand.


An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients.

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