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Trends Immunol. 2010 Oct;31(10):370-6. doi: 10.1016/ Epub 2010 Sep 9.

Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection.

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Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge CB223AT, UK.


The progressive maturation of T cells is accompanied by their migration through the thymus, with each selection stage occurring in distinct microenvironments. Many specialized receptor-ligand pairs have been defined that drive T cell differentiation, but our understanding of the complex relationship between T cells and the thymic stroma is incomplete. Recent reports have identified a role for the chemokine stromal cell-derived factor 1α and its receptor CXC chemokine receptor 4 in β-selection. This review explores these findings in detail.

[Indexed for MEDLINE]

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