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FEBS Lett. 2010 Dec 15;584(24):4845-50. doi: 10.1016/j.febslet.2010.09.001. Epub 2010 Sep 7.

Cytoskeletal cross-talk in the control of T cell antigen receptor signaling.

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Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France.


T cell antigen receptor signaling is triggered and controlled in specialized cellular interfaces formed between T cells and antigen-presenting cells named immunological synapses. Both microtubules and actin cytoskeleton rearrange at the immunological synapse in response to T cell receptor triggering, ensuring in turn the accuracy of intracellular signaling. Recent reports show that the cross-talk between the cortical actin cytoskeleton and microtubule networks is key for structuring the immunological synapse and for controlling T cell receptor signaling. Immunological synapse architecture and the interaction between the signaling machinery and various cytoskeletal elements are therefore crucial for the fine-tuning of T cell signaling.

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