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J Mol Med (Berl). 2010 Oct;88(10):987-91. doi: 10.1007/s00109-010-0675-5. Epub 2010 Sep 8.

Role of mitofusin 2 in cardiovascular oxidative injury.

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1
Institute of Molecular Medicine, Peking University, Beijing, 100871, People's Republic of China.

Abstract

Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential, and mtDNA stability. Dysfunction of mitochondrial dynamics has been implicated in various human diseases, especially in neurodegenerative diseases. Emerging evidence indicates that impaired expression of mitochondrial fusion proteins or their malfunction participates in oxidative stress-induced cardiovascular injury. This review will focus on recent advances of mitochondrial fusion in regulating various cellular processes in cardiovascular system.

PMID:
20824264
DOI:
10.1007/s00109-010-0675-5
[Indexed for MEDLINE]
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