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PLoS One. 2010 Sep 1;5(9). pii: e12496. doi: 10.1371/journal.pone.0012496.

An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis.

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1
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

Abstract

BACKGROUND:

Multiple sclerosis (MS) appears to develop in genetically susceptible individuals as a result of environmental exposures. Epstein-Barr virus (EBV) infection is an almost universal finding among individuals with MS. Symptomatic EBV infection as manifested by infectious mononucleosis (IM) has been shown in a previous meta-analysis to be associated with the risk of MS, however a number of much larger studies have since been published.

METHODS/PRINCIPAL FINDINGS:

We performed a Medline search to identify articles published since the original meta-analysis investigating MS risk following IM. A total of 18 articles were included in this study, including 19390 MS patients and 16007 controls. We calculated the relative risk of MS following IM using a generic inverse variance with random effects model. This showed that the risk of MS was strongly associated with IM (relative risk (RR) 2.17; 95% confidence interval 1.97-2.39; p<10(-54)).

DISCUSSION:

Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis. Future work should focus on the mechanism of this association and interaction with other risk factors.

PMID:
20824132
PMCID:
PMC2931696
DOI:
10.1371/journal.pone.0012496
[Indexed for MEDLINE]
Free PMC Article
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