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Cell Mol Life Sci. 2011 Jan;68(1):55-69. doi: 10.1007/s00018-010-0512-6. Epub 2010 Sep 4.

Comparing peripheral glial cell differentiation in Drosophila and vertebrates.

Author information

1
Institut für Neurobiologie, Badestr. 9, 48149, Münster, Germany.

Abstract

In all complex organisms, the peripheral nerves ensure the portage of information from the periphery to central computing and back again. Axons are in part amazingly long and are accompanied by several different glial cell types. These peripheral glial cells ensure electrical conductance, most likely nature the long axon, and establish and maintain a barrier towards extracellular body fluids. Recent work has revealed a surprisingly similar organization of peripheral nerves of vertebrates and Drosophila. Thus, the genetic dissection of glial differentiation in Drosophila may also advance our understanding of basic principles underlying the development of peripheral nerves in vertebrates.

PMID:
20820850
DOI:
10.1007/s00018-010-0512-6
[Indexed for MEDLINE]

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