Format

Send to

Choose Destination
J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):3-8. doi: 10.1093/gerona/glq158. Epub 2010 Sep 5.

Determinants of serum-induced SIRT1 expression in older men: the CHAMP study.

Author information

1
Centre for Education and Research on Ageing, Concord Repatriation General Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia. david.lecouteur@sydney.edu.au

Abstract

Circulating factors that have an effect on SIRT1 expression are influenced by caloric restriction. To determine the association between frailty and such circulating factors, we measured serum-induced SIRT1 expression from a nested cohort of frail (n = 77) and robust (n = 82) participants from Concord Health and Ageing in Men Project, a population-based study of community-dwelling men older than 70 years. Serum-induced SIRT1 expression was not different between frail and robust men (103.1 ± 17.0 versus 100.4 ± 19.3 μg/L). However, subsequent analyses showed that men with the lowest values (first quartile) were less likely to be frail (odds ratio = 0.5, 95% confidence interval = 0.2-1.0, p = .04) and had higher total body lean mass (p = .001) than the other participants. Serum-induced SIRT1 expression did not correlate with age, diseases, medications, albumin, fasting glucose, or lipids. Overall, there was no association between frailty and serum-induced SIRT1 expression; however, post hoc analysis suggested that there might be a paradoxical association between low serum-induced SIRT1 expression and robustness.

PMID:
20819794
PMCID:
PMC4007825
DOI:
10.1093/gerona/glq158
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center