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Int J Tuberc Lung Dis. 2010 Sep;14(9):1159-63.

Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.

Author information

1
Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, India.

Abstract

BACKGROUND:

Development of tuberculosis (TB) disease is an outcome of complex host-pathogen interactions. The purinergic P2X(7) receptors are adenosine triphosphate gated molecules shown to induce killing of intracellular Mycobacterium tuberculosis, followed by apoptosis of the infected macrophage. A single nucleotide polymorphism in exon 13 of the P2X(7) receptors gene at +1513 position has been shown to abolish the function of this receptor and to be associated with increased susceptibility to TB in some ethnic groups.

OBJECTIVE:

To explore the association of +1513 (A-->C) polymorphism in TB patients in Punjab, North India.

DESIGN:

A case-control study was conducted by studying peripheral blood samples from 204 TB patients (181 pulmonary, 23 extra-pulmonary) and 177 controls with no history of TB. P2X(7) +1513 (A-->C) polymorphism was studied using amplification refractory mutation system analysis.

RESULT:

The distribution of +1513 A/C genotypes in the TB patient and the control groups revealed a statistically significant association with TB (P = 0.002).

CONCLUSION:

The +1513C allele is a risk factor for the development of TB in the North Indian Punjabi population.

PMID:
20819262
[Indexed for MEDLINE]

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