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Nat Struct Mol Biol. 2010 Oct;17(10):1269-71. doi: 10.1038/nsmb.1890. Epub 2010 Sep 5.

The exon junction complex differentially marks spliced junctions.

Author information

1
Institut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique/ UMR 8197, Paris, France.

Abstract

The exon junction complex (EJC), which is deposited onto mRNAs as a consequence of splicing, is involved in multiple post-transcriptional events in metazoa. Here, using Drosophila melanogaster cells, we show that only some introns trigger EJC-dependent nonsense-mediated mRNA decay and that EJC association with particular spliced junctions depends on RNA cis-acting sequences. This study provides the first evidence to our knowledge that EJC deposition is not constitutive but instead is a regulated process.

PMID:
20818392
DOI:
10.1038/nsmb.1890
[Indexed for MEDLINE]

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