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J Pediatr Gastroenterol Nutr. 2010 Nov;51(5):675-7. doi: 10.1097/MPG.0b013e3181e85b22.

Regulatory T cells and T helper subsets in breast-fed infants with hematochezia caused by allergic colitis.

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1
Research Group for Pediatrics and Nephrology, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary.

Abstract

The objective of our study was to investigate the prevalence of CD4 T lymphocyte subsets and their commitment to TH1 or TH2 direction in 10 infants with allergic colitis (AC) and 10 healthy controls. Infants with AC presented with a higher ratio of naïve to memory cells, lower prevalence of activated CD4CD25 cells and FoxP3 regulatory cells, and a shift to TH2 direction in balance compared with controls. These alterations are normalized upon cessation of AC symptoms on elemental L-amino acid formula. These findings suggest the importance of antigen exposure in AC in infancy.

PMID:
20818268
DOI:
10.1097/MPG.0b013e3181e85b22
[Indexed for MEDLINE]
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