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Blood Rev. 2010 Nov;24(6):221-5. doi: 10.1016/j.blre.2010.08.001.

Anaemia of prematurity: pathophysiology and treatment.

Author information

1
University of Iowa College of Medicine, 200 Hawkins Drive, C250 GH, Iowa City, IA 52242-1009, United States. ronald-strauss@uiowa.edu

Abstract

Most infants with birth weight <1.0 kg are given multiple red blood cell (RBC) transfusions within the first few weeks of life. The anaemia of prematurity is caused by untimely birth occurring before placental iron transport and fetal erythropoiesis are complete, by phlebotomy blood losses taken for laboratory testing, by low plasma levels of erythropoietin due to both diminished production and accelerated catabolism, by rapid body growth and need for commensurate increase in red cell volume/mass, and by disorders causing RBC losses due to bleeding and/or hemolysis. RBC transfusions are the mainstay of therapy with recombinant human erythropoietin largely unused because it fails to substantially diminish RBC transfusion needs--despite exerting substantial erythropoietic effects on neonatal marrow.

PMID:
20817366
PMCID:
PMC2981681
DOI:
10.1016/j.blre.2010.08.001
[Indexed for MEDLINE]
Free PMC Article

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