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Microbes Infect. 2010 Dec;12(14-15):1111-9. doi: 10.1016/j.micinf.2010.08.008. Epub 2010 Sep 9.

Interleukin-21: a multifunctional regulator of immunity to infections.

Author information

1
Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, BBRB 446; Box 23, Birmingham, AL 35294-2170, USA.

Abstract

Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections.

PMID:
20817119
PMCID:
PMC2998550
DOI:
10.1016/j.micinf.2010.08.008
[Indexed for MEDLINE]
Free PMC Article

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