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Hematol Oncol Clin North Am. 2010 Oct;24(5):885-906. doi: 10.1016/j.hoc.2010.06.003.

Hereditary genodermatoses with cancer predisposition.

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1
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892-7236, USA. gerstenblithm@gmail.com

Abstract

In this article hereditary genodermatoses with cancer predisposition are reviewed, including nevoid basal cell carcinoma syndrome, neurofibromatosis types 1 and 2, tuberous sclerosis complex, xeroderma pigmentosum, and dyskeratosis congenita. Hereditary melanoma is also included, though it differs from the others in several respects. The underlying genetic aberrations causing these syndromes are largely known, allowing novel treatments to be developed for some of these disorders. Early recognition and diagnosis allows for close follow-up and surveillance for associated malignancies.

PMID:
20816579
PMCID:
PMC3276063
DOI:
10.1016/j.hoc.2010.06.003
[Indexed for MEDLINE]
Free PMC Article
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