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Curr Top Dev Biol. 2010;92:201-30. doi: 10.1016/S0070-2153(10)92006-1.

Gamma-secretase and the intramembrane proteolysis of Notch.

Author information

1
Center for Human Genetics, KULeuven, Leuven, Belgium.

Abstract

Gamma-secretase is the crucial proteolytic activity that releases the Notch intracellular domain and is therefore a central player in the canonical Notch-signaling transduction pathway. We discuss here briefly the discovery of gamma-secretase and what is known on its structure and function. Recent work also indicates that the assembly and activity of gamma-secretase might be regulated by novel cell biological mechanisms. Finally we explore the recent insight that there are several gamma-secretase complexes in mammalian and discuss possibilities to use gamma-secretase as a drug target in Alzheimer's disease and cancer.

PMID:
20816396
DOI:
10.1016/S0070-2153(10)92006-1
[Indexed for MEDLINE]

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