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Cell Metab. 2010 Sep 8;12(3):211-2. doi: 10.1016/j.cmet.2010.08.008.

Assembling complex I with ACAD9.

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1
University of California, San Diego, La Jolla, 92093-0322, USA. ischeffler@ucsd.edu

Abstract

Acyl-Co dehydrogenase 9 (ACAD9) was thought to play a role in fatty acid oxidation. Nouws et al. (2010) reveal a novel and essential role for this enzyme in mitochondrial complex I assembly. A mutation in ACAD9 causes an isolated complex I deficiency in a subset of patients with mitochondrial disease.

PMID:
20816087
DOI:
10.1016/j.cmet.2010.08.008
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