Format

Send to

Choose Destination
Expert Opin Investig Drugs. 2010 Nov;19(11):1339-54. doi: 10.1517/13543784.2010.515585. Epub 2010 Sep 6.

Overcoming platinum resistance in ovarian carcinoma.

Author information

1
University of Southern California, Norris Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 2020 Zonal Avenue, Rm 522, Los Angeles, CA 90033, USA. koji.matsuo@gmail.com

Abstract

IMPORTANCE OF THE FIELD:

Ovarian cancer remains a deadly malignancy because most patients develop recurrent disease that is resistant to chemotherapy, including platinum. Because response rates for current treatment regimens are relatively similar and unfortunately low, no standard chemotherapy for platinum-resistant ovarian cancer exists.

AREAS COVERED IN THIS REVIEW:

A systematic literature review of clinical studies published between January 2005 and March 2010 was conducted using search engines, PubMed and MEDLINE with the entry keywords 'ovarian cancer' and 'platinum resistance'. This search revealed 40 clinical trials (1793 patients).

WHAT THE READER WILL GAIN:

Gemcitabine was the most common drug used in clinical trials reporting higher response rates, ≥ +1 SD of overall response rate (5 out of 8). Gemcitabine-based combination therapy showed an average response rate of 27.2% (95% CI, 22.4-32.0). Combination of gemcitabine and pegylated liposomal doxorubicin (PLD) was the most common regimen (n = 3) and was associated with possible additive effects in platinum-resistant ovarian cancer patients: response rate, gemcitabine alone 6.1%, PLD alone 19.8%, and gemcitabine with PLD 28.7% (95% CI, 20.4-37.0), respectively.

TAKE HOME MESSAGE:

Analysis of recent clinical trials showed that gemcitabine-based combination chemotherapy was associated with the highest antitumor effects in platinum-resistant ovarian cancer patients during the study period.

PMID:
20815774
PMCID:
PMC2962713
DOI:
10.1517/13543784.2010.515585
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center