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Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2106-13. doi: 10.1161/ATVBAHA.110.214403. Epub 2010 Sep 2.

Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.

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1
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.

Abstract

OBJECTIVE:

To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake.

METHODS AND RESULTS:

Gpihbp1(-/-) mice were fed a Western diet containing 0.15% cholesterol. After 4 to 8 weeks, their plasma triglyceride levels were 113 to 135 mmol/L. When 0.005% ezetimibe was added to the diet to block cholesterol absorption, Lpl expression in the liver was reduced significantly, and the plasma triglyceride levels were significantly higher (>170 mmol/L). We also assessed plasma triglyceride levels in Gpihbp1(-/-) mice fed Western diets containing either high (1.3%) or low (0.05%) amounts of cholesterol. The high-cholesterol diet significantly increased Lpl expression in the liver and lowered plasma triglyceride levels.

CONCLUSIONS:

Treatment of Gpihbp1(-/-) mice with ezetimibe lowers Lpl expression in the liver and increases plasma triglyceride levels. A high-cholesterol diet had the opposite effects. Thus, cholesterol intake modulates plasma triglyceride levels in Gpihbp1(-/-) mice.

PMID:
20814015
PMCID:
PMC2959134
DOI:
10.1161/ATVBAHA.110.214403
[Indexed for MEDLINE]
Free PMC Article
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