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Int Rev Neurobiol. 2010;91:205-33. doi: 10.1016/S0074-7742(10)91007-6.

Glutamate plasticity in the drunken amygdala: the making of an anxious synapse.

Author information

1
Department of Physiology & Pharmcology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Abstract

Plasticity at glutamatergic synapses is believed to be the cellular correlate of learning and memory. Classic fear conditioning, for example, is dependent upon NMDA-type glutamate receptor activation in the lateral/basolateral amygdala followed by increased synaptic expression of AMPA-type glutamate receptors. This review provides an extensive comparison between the initiation and expression of glutamatergic plasticity during learning/memory and glutamatergic alterations associated with chronic ethanol exposure and withdrawal. The parallels between these neuro-adaptive processes suggest that long-term ethanol exposure might "chemically condition" amygdala-dependent fear/anxiety via the increased function of pre- and post-synaptic glutamate signaling.

PMID:
20813244
PMCID:
PMC3032604
DOI:
10.1016/S0074-7742(10)91007-6
[Indexed for MEDLINE]
Free PMC Article

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