Format

Send to

Choose Destination
See comment in PubMed Commons below
Int Rev Neurobiol. 2010;91:95-128. doi: 10.1016/S0074-7742(10)91004-0.

Using expression genetics to study the neurobiology of ethanol and alcoholism.

Author information

1
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

Abstract

Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have produced prodigious data sets on genetic loci, potential candidate genes, and differential gene expression related to alcoholism and ethanol behaviors. Validated target genes or gene networks functioning in alcoholism are still of meager proportions. Genetical genomics, which combines genetic analysis of both traditional phenotypes and whole genome expression data, offers a potential methodology for characterizing brain gene networks functioning in alcoholism. This chapter will describe concepts, approaches, and recent findings in the field of genetical genomics as it applies to alcohol research.

PMID:
20813241
PMCID:
PMC3427772
DOI:
10.1016/S0074-7742(10)91004-0
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center