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Amyotroph Lateral Scler. 2010 Dec;11(6):555-7. doi: 10.3109/17482968.2010.513053. Epub 2010 Sep 3.

No evidence of microbleeds in ALS patients at 7 Tesla MRI.

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Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht.


There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.

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