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J Am Chem Soc. 2010 Sep 29;132(38):13194-6. doi: 10.1021/ja1066459.

Direct C-H arylation of electron-deficient heterocycles with arylboronic acids.

Author information

1
Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods.

PMID:
20812741
PMCID:
PMC2946225
DOI:
10.1021/ja1066459
[Indexed for MEDLINE]
Free PMC Article

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