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Nat Cell Biol. 2010 Sep;12(9):842-6. doi: 10.1038/ncb0910-842.

Can autophagy promote longevity?

Author information

1
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.

Abstract

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.

PMID:
20811357
DOI:
10.1038/ncb0910-842
[Indexed for MEDLINE]

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