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Pediatr Infect Dis J. 2011 Feb;30(2):161-3. doi: 10.1097/INF.0b013e3181f43906.

Severe pertussis in infants: estimated impact of first vaccine dose at 6 versus 8 weeks in australia.

Author information

1
Communicable Disease and Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Australian Government, Canberra, Australia. ruth.foxwell@health.gov.au

Abstract

We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

PMID:
20811313
DOI:
10.1097/INF.0b013e3181f43906
[Indexed for MEDLINE]

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