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Pediatr Infect Dis J. 2011 Feb;30(2):161-3. doi: 10.1097/INF.0b013e3181f43906.

Severe pertussis in infants: estimated impact of first vaccine dose at 6 versus 8 weeks in australia.

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Communicable Disease and Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Australian Government, Canberra, Australia.


We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.

[Indexed for MEDLINE]

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