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Genes Dev. 2010 Sep 1;24(17):1832-60. doi: 10.1101/gad.1956510.

tRNA biology charges to the front.

Author information

1
Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA. eric_phizicky@urmc.rochester.edu

Abstract

tRNA biology has come of age, revealing an unprecedented level of understanding and many unexpected discoveries along the way. This review highlights new findings on the diverse pathways of tRNA maturation, and on the formation and function of a number of modifications. Topics of special focus include the regulation of tRNA biosynthesis, quality control tRNA turnover mechanisms, widespread tRNA cleavage pathways activated in response to stress and other growth conditions, emerging evidence of signaling pathways involving tRNA and cleavage fragments, and the sophisticated intracellular tRNA trafficking that occurs during and after biosynthesis.

PMID:
20810645
PMCID:
PMC2932967
DOI:
10.1101/gad.1956510
[Indexed for MEDLINE]
Free PMC Article

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