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Genes Dev. 2010 Sep 1;24(17):1827-31. doi: 10.1101/gad.1972810.

The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule?

Author information

1
Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

She2p is an RNA-binding protein that recognizes a zipcode on specific mRNAs necessary for the assembly of a protein complex that localizes them to the yeast bud tip. In this issue of Genes & Development, Shen and colleagues (pp. 1914-1926) demonstrate that She2p associates with RNAPII globally, but then recognizes the nascent chain only if it contains a zipcode. This demonstrates yet another case where the mRNA's cytoplasmic fate is determined by the RNAPII complex.

PMID:
20810644
PMCID:
PMC2932966
DOI:
10.1101/gad.1972810
[Indexed for MEDLINE]
Free PMC Article

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