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Trends Immunol. 2010 Oct;31(10):377-83. doi: 10.1016/j.it.2010.07.001. Epub 2010 Aug 31.

The elusive identity of T follicular helper cells.

Author information

1
Immunology, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.

Abstract

Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secretion are exclusive properties of T cells that help B cells, and not all follicular T cells are B cell helpers. Indeed some follicular T cells appear to be suppressive. Furthermore, Tfh cells evolve during an immune response and B cells that have recently bound antigen, germinal center (GC) B cells and plasmablasts interact with phenotypically distinct Tfh cells. Here we propose that distinction between non-GC Tfh and GC Tfh cells might reconcile emerging controversies on Tfh cytokine secretion and the requirement of T-B cell interactions and SAP expression for Tfh formation.

PMID:
20810318
DOI:
10.1016/j.it.2010.07.001
[Indexed for MEDLINE]

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