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Pediatr Dermatol. 2010 Sep-Oct;27(5):533-4. doi: 10.1111/j.1525-1470.2010.01259.x. Epub 2010 Aug 27.

Congenital yellow nail syndrome: a case report and its relationship to nonimmune fetal hydrops.

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As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait.


Yellow nail syndrome (YNS) is an uncommon disorder characterized by a triad of nail dystrophy, lymphedema, and pleural effusion. It is rare in children and congenital occurrence of YNS has been very rarely described. We report a 2-year-old Arab boy having congenital yellow nail syndrome with mild facial dysmorphism and bilateral conjunctival pigmentation born to consanguineous parents. One of his older siblings had died of nonimmune fetal hydrops (NIFH). The case supports the genetic basis of yellow nail syndrome with a possible relationship to nonimmune fetal hydrops.

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