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Nephron Clin Pract. 2011;117(3):c253-8. doi: 10.1159/000320194. Epub 2010 Aug 31.

Single nucleotide polymorphisms in the phospholipase A2 receptor gene are associated with genetic susceptibility to idiopathic membranous nephropathy.

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1
Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea.

Abstract

BACKGROUND:

The phospholipase A(2) receptor (PLA2R) is a major antigen found in patients with idiopathic membranous nephropathy (MN). The relationship of genetic polymorphisms of PLA2R with the susceptibility and clinical outcomes of this disease is unknown.

METHODS:

We studied 199 patients with idiopathic MN followed up for 3.7 ± 3.2 years. We enrolled 33 patients with secondary MN and 356 subjects with normal blood pressure and no proteinuria. PLA2R single nucleotide polymorphisms (SNPs) were genotyped.

RESULTS:

The allele frequencies of C in rs35771982 and G in rs3828323 were 73.6 and 73.9%, respectively. Subjects with the CC genotype in rs35771982 had a higher susceptibility to idiopathic MN compared to subjects with other genotypes (odds ratio 2.6; 95% confidence interval 1.8-4.0). Patients with secondary MN were not different from controls with regard to PLA2R genotype. No impact of genetic polymorphisms on renal survival was detected.

CONCLUSION:

The findings of this study suggest that PLA2R SNPs might be associated with the risk of developing MN.

PMID:
20805699
DOI:
10.1159/000320194
[Indexed for MEDLINE]

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