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QJM. 2010 Nov;103(11):831-6. doi: 10.1093/qjmed/hcq148. Epub 2010 Aug 30.

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link.

Author information

1
Conway Institute for Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.

Abstract

Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.

PMID:
20805118
PMCID:
PMC2955282
DOI:
10.1093/qjmed/hcq148
[Indexed for MEDLINE]
Free PMC Article

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