Send to

Choose Destination
Dermatol Online J. 2010 Aug 15;16(8):8.

Paraneoplastic Acanthosis Nigricans: The importance of exhaustive and repeated malignancy screening.

Author information

Barts and The London NHS Trust, London, UK.


Paraneoplastic acanthosis nigricans (P-AN) characteristically has a sudden onset, rapid progression, and extensive cutaneous involvement. The association between P-AN and internal malignancy is well established and the most common association is with adenocarcinoma of gastrointestinal origin. We present the case of an 81-year-old man with a 12-month history of anorexia, weight loss, and clinical evidence of extensive acanthosis nigricans. After exhaustive and repeated investigations a papillary thyroid carcinoma and a follicular adenoma were identified and he improved upon its resection. To our knowledge, P-AN in association with thyroid neoplasm has been reported on only one previous occasion.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Arthur C Huntley MD, California Digital Library
Loading ...
Support Center