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Cytoskeleton (Hoboken). 2010 Sep;67(9):545-54. doi: 10.1002/cm.20472.

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.

Author information

1
Department of Cell Pharmacology, Nagoya University, Showa-ku, Japan.

Abstract

Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase.

PMID:
20803696
PMCID:
PMC3038199
DOI:
10.1002/cm.20472
[Indexed for MEDLINE]
Free PMC Article

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