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Bioorg Med Chem Lett. 2010 Oct 1;20(19):5666-9. doi: 10.1016/j.bmcl.2010.08.023. Epub 2010 Aug 8.

6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics.

Author information

1
Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, United States. dafavor@gmail.com

Abstract

A series of 6-alkoxyisoindolin-1-ones with a magic shotgun pharmacological profile are presented as potential antipsychotics. The in vitro pharmacological profile includes D(2) partial agonism (30-55%), 5-HT(1A) partial agonism (60-90%), and 5-HT(2A) antagonism. Selected compounds in this series displayed good in vivo activity and potency.

PMID:
20801650
DOI:
10.1016/j.bmcl.2010.08.023
[Indexed for MEDLINE]

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