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Fertil Steril. 2011 Jan;95(1):307-9. doi: 10.1016/j.fertnstert.2010.07.1073.

GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles.

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1
Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. mikib@tasmc.health.gov.il

Abstract

To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01032421.

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