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Curr Opin Cell Biol. 2010 Dec;22(6):845-51. doi: 10.1016/j.ceb.2010.08.002. Epub 2010 Aug 26.

Apoptosis: embedded in membranes.

Author information

1
Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Room 4H-41, Hamilton, Ontario, Canada L8N 3Z5.

Abstract

Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.

PMID:
20801011
DOI:
10.1016/j.ceb.2010.08.002
[Indexed for MEDLINE]

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