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Bioorg Med Chem Lett. 2010 Oct 1;20(19):5772-5. doi: 10.1016/j.bmcl.2010.07.137. Epub 2010 Aug 6.

Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line.

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1
Molecular Research Lab, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.

PMID:
20800481
DOI:
10.1016/j.bmcl.2010.07.137
[Indexed for MEDLINE]
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