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J Card Fail. 2010 Sep;16(9):734-41. doi: 10.1016/j.cardfail.2010.04.009. Epub 2010 Jun 8.

Cost-effectiveness of implantable cardioverter-defibrillators in children with dilated cardiomyopathy.

Author information

1
Division of Pediatric Cardiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. brian.feingold@chp.edu

Abstract

BACKGROUND:

Implantable cardioverter-defibrillators (ICDs) improve survival and are cost-effective in adults with poor left ventricular function. Because of differences in heart failure etiology, sudden death rates, and ICD complication rates, these findings may not be applicable to children.

METHODS AND RESULTS:

We developed a Markov model to compare typical management of childhood dilated cardiomyopathy with symptomatic heart failure to prophylactic ICD implantation plus typical management. Model costs included costs of outpatient care, medications, complications, and transplantation. Time horizon was up to 20 years from model entry. Total costs were $433,000 (ICD strategy) and $355,000 (typical management). Although quality adjusted survival was greater in the ICD group (6.78 versus 6.43 quality adjusted life-years [QALY]), the incremental cost-utility ratio was $281,622/QALY saved with the ICD strategy. In sensitivity analyses, the ICD strategy cost less than the $100,000/QALY benchmark for cost-effectiveness only when the annual probability of sudden death exceeded 13% or when strong, sustained benefits in quality of life from the ICD were assumed.

CONCLUSIONS:

Prophylactic ICD use in children with dilated cardiomyopathy, poor ventricular function, and symptomatic heart failure does not appear to be cost-effective. This is likely due to lower sudden death rates in this population.

PMID:
20797597
PMCID:
PMC2929392
DOI:
10.1016/j.cardfail.2010.04.009
[Indexed for MEDLINE]
Free PMC Article
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