Format

Send to

Choose Destination
See comment in PubMed Commons below
BMB Rep. 2010 Aug;43(8):524-9.

New understanding of glucocorticoid action in bone cells.

Author information

1
Skeletal Diseases Genome Research Center, Department of Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea. biohjk@knu.ac.kr.

Abstract

Glucocorticoids (GCs) are useful drugs for the treatment of various diseases, but their use for prolonged periods can cause severe side effects such as osteoporosis. GCs have a direct effect on bone cells, where they can arrest bone formation, in part through the inhibition of osteoblast. On the other hand, GCs potently suppress osteoclast resorptive activity by disrupting its cytoskeleton based on the inhibition of RhoA, Rac and Vav3 in response to macrophage colony-stimulating factor. GCs also interfere with microtubule distribution and stability, which are critical for cytoskeletal organization in osteoclasts. Thus, GCs inhibit microtubule-dependent cytoskeletal organization in osteoclasts, which, in the context of bone remodeling, further dampens bone formation.

PMID:
20797313
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Korean Society for Biochemistry and Molecular Biology
    Loading ...
    Support Center