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Oral Dis. 2011 Mar;17(2):206-9. doi: 10.1111/j.1601-0825.2010.01722.x. Epub 2010 Aug 27.

Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus.

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1
Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok, Thailand.

Abstract

OBJECTIVE:

 This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances.

MATERIALS AND METHODS:

 Genomic DNA from 75 Thai patients with OLP and 154 healthy controls were genotyped for TNF-α polymorphisms-- -863(rs1800630), -308(rs1800629), and -238(rs361525)--using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS:

 We found a higher proportion of TNF-alpha-308 AA genotype (high producer genotype) among OLP patients (5/75; 6.67%) when compared to healthy controls (1/154; 0.65%; OR = 10.93; 95% CI = 1.21-251.9). For other polymorphisms (-863 and -238), we did not find any significant association with OLP development; this was also the case with haplotype analysis (-863/-308/-238).

CONCLUSION:

 TNF-α-308AA may play a relevant role in the susceptibility and severity of OLP in the Thai population. However, further investigation of this study is needed.

[Indexed for MEDLINE]

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