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Dev Pharmacol Ther. 1990;15(2):61-7.

Use of a beta-agonist in ventilated, very-low-birth-weight babies: a longitudinal evaluation.

Author information

1
Division of Neonatology, Albert Einstein Medical Center, Philadelphia, Pa.

Abstract

To determine if there is a specific postnatal (PNA) or postconceptional age (PCA) at which ventilated preterm infants respond to beta-agonists, we evaluated 15 infants with a mean gestational age of 26.5 +/- 1.5 weeks and mean birth weight of 0.89 +/- 0.23 kg who required mechanical ventilation at 10 days of age. Weekly pulmonary function testing (PFT) was performed before and 1 h after administration of albuterol. Taking the group as a whole, as well as individual babies, regression analysis showed no relationship between positive response and either PNA or PCA. Evaluation of individual infants, however, showed that some consistently responded to beta-agonists whereas others did not. We recommend individual PFT to identify those infants who will benefit from use of beta-agonists.

PMID:
2078974
[Indexed for MEDLINE]

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