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Neuropsychopharmacology. 1990 Oct-Dec;3(5-6):457-71.

Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems.

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  • 1Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892.


Most evaluations of the contributions of possible alterations in serotonergic neurotransmission to the etiology and treatment of neuropsychiatric disorders preceded the recent explosion of information regarding multiple serotonin (5-HT) receptors and brain 5-HT subsystems. This review provides an appraisal of some examples where drugs acting at different 5-HT receptor subtypes have provided new treatment or have contributed to the development of knowledge regarding various neuropsychiatric disorders, including anxiety, panic disorder, obsessive-compulsive disorder, depression, schizophrenia, alcoholism, migraine, sexual dysfunction, and Alzheimer's disease.

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