Subacute axonal neuropathy in Parkinson's disease with cobalamin and vitamin B6 deficiency under duodopa therapy

Mov Disord. 2010 Aug 15;25(11):1748-52. doi: 10.1002/mds.23342.

Abstract

We describe two patients who developed subacute axonal peripheral neuropathy under duodopa treatment. Comprehensive diagnostic workup including muscle and sural nerve biopsy revealed that the most probable cause of subacute axonal peripheral neuropathy was cobalamin and vitamin B6 deficiency in both the patients.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiparkinson Agents / adverse effects
  • Dihydroxyphenylalanine / administration & dosage
  • Dihydroxyphenylalanine / adverse effects
  • Drug Administration Routes
  • Female
  • Humans
  • Male
  • Parkinson Disease / drug therapy
  • Peripheral Nervous System Diseases / drug therapy*
  • Peripheral Nervous System Diseases / etiology
  • Vitamin B 12 / therapeutic use*
  • Vitamin B 6 Deficiency / chemically induced
  • Vitamin B 6 Deficiency / drug therapy*
  • Vitamin B Complex / therapeutic use*

Substances

  • Antiparkinson Agents
  • Vitamin B Complex
  • Dihydroxyphenylalanine
  • Vitamin B 12