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Tuberculosis (Edinb). 2010 Sep;90(5):298-300. doi: 10.1016/j.tube.2010.08.002. Epub 2010 Aug 23.

The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.

Author information

1
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-8128, USA. joelf@tamu.edu

Abstract

The antimycobacterial efficacy of the abyssomicin C family of natural products, in addition to a key synthetic intermediate, has been investigated given their reported inhibition of Bacillus subtilis p-aminobenzoate biosynthesis. The naturally occurring (-)-abyssomicin C and its atropisomer were found to exhibit low micromolar growth inhibition against the relatively fast-growing and non-virulent Mycobacterium smegmatis and the vaccine strain Mycobacterium bovis BCG, while their antipodes were slightly less active. (-)-abyssomicin C and its atropisomer were particularly efficacious against Mycobacterium tuberculosis H37Rv, exhibiting MIC values of 3.6 and 7.2 μM, respectively. More specifically, (-)-abyssomicin C was bactericidal. This complex natural product and its analogs, thus, hold promise as chemical tools in the study of M. tuberculosis metabolism.

PMID:
20739223
PMCID:
PMC3213896
DOI:
10.1016/j.tube.2010.08.002
[Indexed for MEDLINE]
Free PMC Article

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