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Hum Psychopharmacol. 2010 Aug;25(6):509-13. doi: 10.1002/hup.1145.

A double-blind, placebo-controlled pilot study of ondansetron for patients with obsessive-compulsive disorder.

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1
Department of Anesthesiology, Jundishapur University of Medical Sciences, Ahwaz, Iran.

Abstract

OBJECTIVE:

To assess the efficacy and tolerability of ondansetron in combination with selective serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD).

METHODS:

The study was an 8-week pilot double-blind randomized clinical trial. Forty-two adult outpatients who met the Diagnostic and Statistical Manual, Fourth Edition, Text Revision (DSM-IV-TR) criteria for OCD based on the structured clinical interview participated in the trial. In this study, patients were randomly assigned to receive either ondansetron (4 mg) plus fluoxetine or fluoxetine (20 mg/day) plus placebo.

RESULTS:

The results showed a significant difference between two groups in the treatment of OCD (based on t-test). There was not any significant difference between the two groups in terms of observed side effects.

CONCLUSIONS:

The results of this study show that ondansetron has positive effects on obsession and compulsion which start two weeks after the beginning of the treatment.

PMID:
20737524
DOI:
10.1002/hup.1145
[Indexed for MEDLINE]
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