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Neuropsychopharmacology. 2011 Jan;36(1):98-113. doi: 10.1038/npp.2010.121. Epub 2010 Aug 25.

Serotonin and dopamine: unifying affective, activational, and decision functions.

Author information

1
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands. roshan.cools@gmail.com

Abstract

Serotonin, like dopamine (DA), has long been implicated in adaptive behavior, including decision making and reinforcement learning. However, although the two neuromodulators are tightly related and have a similar degree of functional importance, compared with DA, we have a much less specific understanding about the mechanisms by which serotonin affects behavior. Here, we draw on recent work on computational models of dopaminergic function to suggest a framework by which many of the seemingly diverse functions associated with both DA and serotonin-comprising both affective and activational ones, as well as a number of other functions not overtly related to either-can be seen as consequences of a single root mechanism.

PMID:
20736991
PMCID:
PMC3055512
DOI:
10.1038/npp.2010.121
[Indexed for MEDLINE]
Free PMC Article

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