Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Cancer. 2010 Sep 7;103(6):772-5. doi: 10.1038/sj.bjc.6605828. Epub 2010 Aug 24.

Nasal septum perforation: a side effect of bevacizumab chemotherapy in breast cancer patients.

Author information

1
Breast Cancer Department, Centre Oscar Lambret, 3 rue F Combemale, Lille 59000, France. a-mailliez@o-lambret.fr

Abstract

BACKGROUND:

Bevacizumab is an anti-vascular endothelial growth factor approved in association with paclitaxel or docetaxel as first line in patients (pts) with metastatic breast cancer. Rare cases of nasal septum perforations have been reported. We report our experience of nasal perforation in breast cancer pts receiving bevacizumab and chemotherapy either in the adjuvant or in the metastatic settings.

METHODS:

Between 1 January and 31 December 2009, 70 pts received bevacizumab together with chemotherapy. All the pts who had received bevacizumab were referred to the ENT specialist. Symptoms potentially related were looked for. Side effects were graded according to CTCAE.

RESULTS:

Five nasal septum perforations were diagnosed (5 out of 70; 7.14%). Bevacizumab dose was 15 mg kg(-1) 3 weekly. Three pts were metastatic. Bevacizumab was associated with docetaxel (100 mg m(-2) every 3 weeks) in two pts and with weekly paclitaxel in one. The last two pts received bevacizumab in combination with anthracyclin and then taxanes in the adjuvant setting. In these two cases, nasal septum perforation occurred at the time of docetaxel treatment.

CONCLUSION:

A high incidence of nasal septum perforation has been shown in pts with breast cancer receiving bevacizumab together with chemotherapy. Several mechanisms could be involved (mucositis, delayed tissue repair, antiangiogenic action of taxanes).

PMID:
20736943
PMCID:
PMC2966623
DOI:
10.1038/sj.bjc.6605828
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center