Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2010 Oct 27;21(15):963-7. doi: 10.1097/WNR.0b013e32833ed111.

Epileptic hypersynchrony revisited.

Author information

Department of Neurosciences, Faculty of Medicine and Pharmacy, University of Mons, Mons, Belgium.


Synchronization of neuronal responses, which allows coordination of distributed activity patterns, is instrumental in brain functioning, as altered neuronal synchronization is involved in a variety of brain pathologies. Epileptic hypersynchrony chiefly relies on brain wiring, which, in a broader sense, means including astrocytic release of gliotransmitters and electrotonic coupling through gap junctions, beyond classical synaptic connections. Epileptic hypersynchrony also relies on electrical field effects and ion concentration changes in the extracellular space, and it relates to intracellular mechanisms underlying neuronal hyperexcitability. The current lack of a specific impact of hypersynchrony on antiepileptic drug development might be next surpassed, as hypersynchrony seems to be a worthy and approachable, though challenging target of antiepileptic pharmacology.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center