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Isr J Psychiatry Relat Sci. 2010;47(2):139-43.

Environmental risk factors for psychopathology.

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Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel.


In the past all psychopathologies were viewed as caused by the environment. Later on case-control and family-based studies of major psychiatric disorders found genetic associations, but in many cases these findings did not survive replications. A gene-environment approach gave new hope for possible associations. Gene environment correlations emphasized that the relationship are bidirectional. However, recent meta-analyses raised doubts about the consistency of these findings as well. The review summarizes the current view on the environmental factors in the major psychopathologies.

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